Loss and grief seem to go hand in hand in relation to FASD and this experience deeply impacts the lives of children, youth, adults, families and support networks. Many children become involved in the child protection system early in their lives and this deeply impacts their life course trajectory including later involvement with the justice system in adolescence and adulthood. Mothers experience loss and grief regarding their child’s disability and frequently lose the opportunity to parent often due to active substance use. Beyond diagnosis, FASD is a complex psychosocial/emotional experience that requires ongoing supports to navigate life on a daily basis. Individuals with FASD often experience mental health challenges, poverty and homelessness. FASD often goes unrecognized by many professionals and this contributes to ineffective support, unrealistic expectations, frustration, loss and grief, all of which contribute to higher levels of vulnerability. Individuals and families have cumulative experiences of loss, grief and hurt, particularly when they feel professionals do not understand their experience and the impact of FASD in daily life. Training on FASD and practicing FASD informed care is essential to minimize further marginalization and oppression of individuals and families. Other losses for Individuals living with FASD include being misunderstood, facing challenges in relationships, ever-present stigma and social exclusion. The COVID-19 Pandemic resulted in a loss of supports for individuals living with FASD creating new and unexpected challenges that we will talk about from a personal, professional and parent perspective.